Abstract
INTERNATIONAL JOURNAL OF ENGINEERING, SCIENCE AND - Volume 7, Issue 4 (2) , April 2018 (Special Issue FBSA)
Pages: 147-152
AT-125 in the modulation of EAC solid tumors
Subhadra Roy?
Category:Engineering, Science and Mathematics
Abstract:
Solid tumors, namely carcinomas, are characterized by the formation of abnormal clumps of cells. These tumors depend highly on VEGF-mediated angiogenesis to grow beyond a certain size. The hostile microenvironment of solid tumors is characterized by lack of oxygen and nutrients. Glutamine, an important nutrient of cells, is avidly consumed by almost all tumor cells, including solid tumors. Malignant cells have a high oxidative glutamine metabolism and there is direct correlation between such oxidation and the degree of malignancy. AT-125 is an analogue of glutamine which is naturally found as a fermentation product of Strepomyces svicei. It is known to regulate tumor growth by hindering glutamine uptake by the rapidly multiplying cells. AT-125 or acivicin, is also known to block de novo purine and pyrimidine biosynthesis in growing cells by inhibiting a number of different glutmine amidotransferases including GMP synthetase and glutamyl transpeptidase. In this study, we report the effect of AT-125 on the growth of solid tumors by Ehrlich ascites carcinoma (EAC) cells in Swiss albino mice. The reduction in tumor growth suggests important role of AT-125 in regulation of solid tumors and warrants the need for further studies in this direction in the future.
Keywords: Solid tumor, At-125; glutamine; angiogenesis.